炎症性肠病与肠道微生态的研究进展

Research progress in inflammatory bowel disease and intestinal microecology

摘要:

炎症性肠病(inflammatory bowel disease，IBD)是一种肠道慢性炎症性疾病，其发病机制尚不清楚。然而，IBD的发病率不断上升给患者及其家属带来了巨大的经济负担，需要找到积极有效的治疗方法来帮助患者。最新的观点认为，宿主和肠道微生物之间的平衡被打破会触发遗传易感个体的免疫炎症反应。肠道菌群失调在炎症性肠病的发病及发展过程中起着重要的作用。临床研究发现，IBD患者肠道菌群失调程度不同，而联合应用益生菌可以改善这些患者的症状。越来越多的研究者密切关注肠道菌群与IBD的关系，并进行了深入的基础和临床研究。本文从肠道菌群对IBD的生理影响以及益生菌和粪便细菌移植等方面进行综述。

Abstract:

Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory disease which pathogenesis is not yet clear. However, the incidence of IBD is increasing, which brings great financial burden to patients and their families. We need to find positive and effective treatments to help them. The latest view is that the balance between the host and the intestinal microorganism is broken, which triggers an immune inflammatory response in genetically susceptible individuals. Imbalance of intestinal flora plays an important role in the pathogenesis and development of IBD. Clinical studies found that IBD patients had varying degrees of intestinal flora imbalance. Combined application of probiotics can improve theses patient's symptoms. More and more researchers are paying close attention to the relationship between intestinal flora and IBD, and have carried out in-depth basic and clinical research. This article reviews the physiological influence of intestinal flora on IBD and the therapeutic effects of probiotics and fecal bacteria transplantation on IBD.