肠道微生物对肠道屏障功能完整性的维护机制研究概况

Maintenance mechanism of intestinal barrier function integrity by intestinal microbes

摘要:

肠道微生物群是一个稳定且复杂的生态系统，可以通过形成菌膜屏障或促进肠道上皮细胞增殖分化等方式形成保护屏障，并在肠道病原菌感染和威胁期间维持和促进免疫稳态中起积极作用。本文重点叙述宿主-肠道微生物相互作用过程中抗病原菌感染的方式，以及肠道微生物参与合成抗菌化合物抵御肠道病原菌入侵和威胁的机制，为调控肠道微生物解决临床胃肠道疾病及其相关症状提供理论参考依据。

Abstract:

The gut microbiota is a stable and complex ecosystem that forms a protective barrier by forming a membrane barrier and promoting proliferation and differentiation of intestinal epithelial cells, and plays an active role in maintaining and promoting immune homeostasis during intestinal pathogen infection and threats. The paper focuses on the mechanism of anti-pathogenic infection in host-intestinal microbial interactions and the involvement of intestinal microbes in the synthesis of antibacterial compounds against intestinal pathogens and threats, and to provide a theoretical reference for regulation of intestinal microbes to solve clinical gastrointestinal diseases and related symptoms.