Abstract:The global epidemic of tuberculosis caused by Mycobacterium tuberculosis (Mtb) is still grim. During host infection, Mtb secretes a series of effector molecules into human macrophage to regulate, modulate host immunization pathway and finally escape from the immune killing. Here, we summarized the critical roles of protein tyrosine phosphatase A (PtpA) during Mtb infection, such as inhibit the innate immunity, apoptosis, phagosome-lysosome fusion by interfering multiple pathways and modulate macrophage bioenergetics state. PtpA has been assumed as an important drug target for a long time. However, it is beset with the high similarity with human protein tyrosine phosphatase hLMW-PTP in inhibitor design and screening. At last, the research status and problems need to be revealed in Mtb PtpA transcriptional regulation and secretion pathway was analyzed and discussed, which will provide us a new way to block PtpA’s function.
