Hybrid teaching model of Microbiology courses based on “Large Lecture Class Combined with Small Tutorial Class” is a valuable model to guarantee the teaching effect when the software and hardware conditions are insufficient, and the main purpose is to implement the “student-centered teaching philosophy”. Teachers explain the contents of the syllabus to students in the “Large Lecture Class”, while provide students with review, case discussion, classroom test and supervise their learning process in the “Small Tutorial class”. This kind of hybrid teaching model changed the students’ role from passive listeners to active participants.