细菌三型分泌系统输出蛋白分泌信号研究进展

Advance in secretion signal of type 3 secreted proteins

摘要:

自提出三型分泌系统的概念以来，相关分子机制的研究让人们对其有了更深入的了解。与依赖信号肽分泌途径形成鲜明对比的是，蛋白通过细菌三型分泌系统分泌或者转运时没有可识别的保守信号序列。近期对三型分泌蛋白的研究发现了多种可以引导其分泌的分泌信号。本文分别介绍了细菌三型分泌系统的种类，分泌系统分泌蛋白的种类，并着重阐述了分泌信号的分子特性及其机制，以期为新型抗菌药物的研发提供新的思路。

Abstract:

Since the concept of a type 3 secretion system was proposed, the study of related molecular mechanisms has furthered our understanding of it. In contrast to the signal peptide in other secretory machineries, there is no conserved signal sequence when the protein is secreted or transported through the bacterial type 3 secretion system. A variety of secretory signals that guide the secretion of type 3 secreted protein have been discovered in the recent study. This article introduces the categories of bacterial type 3 secretion system, the types of secreted proteins in the secretory system and focuses on molecular characters of secretion signals, providing new ideas for the development of new antibacterial drugs.