Src和Abl酪氨酸蛋白激酶家族参与病原微生物感染的研究进展

Research advances in Src and Abl tyrosine protein kinase family involved in pathogenic microbial infection

摘要:

Src和Abl家族激酶属于非受体型酪氨酸激酶(Nonreceptor tyrosine kinase，NRTK)家族重要成员，广泛存在于各种细胞中，参与细胞内信号传递并调节细胞生理过程，它们在维持细胞、组织和器官稳态功能中发挥着至关重要的作用。研究表明，Src和Abl家族激酶通过多种机制参与病原微生物的感染(如与病原微生物的脯氨酸基序-PXXP互作)。因此，从Src和Abl家族激酶角度出发探究病原微生物感染机制逐渐成为一个热点。本文就Src和Abl家族激酶的结构特点以及参与病原微生物感染的研究报道进行综述，以期为病原微生物感染的致病机制、防控和药物研发提供参考。

Abstract:

Src and Abl family kinases are the important members of the nonreceptor tyrosine kinase (NRTK) family, which exist widely in various cell types, participate in different intracellular signaling pathways, and regulate a variety of cellular physiological processes. They play a vital role in maintaining the homeostatic function of the normal cells, tissues and organs. Studies have shown that Src and Abl family kinases are involved in the infection with multiple pathogenic microorganisms through a variety of mechanisms (e.g. interaction with the proline motif-PXXP of the pathogenic microorganism). Therefore, the study of mechanism of pathogenesis of microbial pathogen infection from the perspective of Src and Abl family kinases has become a hot research issue. In this paper, the structural characteristics of Src and Abl family kinases and the reports on the relationship between microbial pathogen infection and host cell kinases are systematically reviewed, which should provide references for the research of pathogenic mechanism, prevention and control and drug development of pathogenic microorganisms.