肠道病原菌III型分泌系统效应蛋白调控宿主细胞NF-κB和MAPK信号通路的研究进展

Research progress in regulating host NF-κB and MAPK pathways by the type III secretion system (T3SS) effectors of intestinal pathogenic bacteria

摘要:

病原细菌感染对人类健康构成了严重的威胁，一类具有III型分泌系统(Type III secretion system，T3SS)的肠道致病细菌可以通过T3SS将效应蛋白“注射”到宿主细胞中，模拟和操纵宿主细胞的多种信号转导通路，包括细胞凋亡、细胞自噬和炎症反应等，从而有效地逃逸宿主的防御，增强感染性和致病性。本文综述了肠道病原菌T3SS效应蛋白在调控宿主炎症反应中NF-κB和MAPK通路的最新研究进展。

Abstract:

Pathogenic bacterial infection poses a serious threat to human health. Intestinal pathogenic bacteria that contain a Type III secretion system (T3SS) can use the T3SS to inject effectors into host cells and manipulate multiple signaling pathways, including apoptosis, autophagy and inflammatory responses pathways, in order to evade host defense system and enhance their infectivity and pathogenicity. Here, we have reviewed the latest research progress in the regulation of host NF-κB and MAPK pathways involved in inflammatory responses by the T3SS effectors of intestinal bacterial pathogens.