In recent years, as a student-centered and teacher-oriented teaching method, flipped classroom has been gradually applied in undergraduate education. This study focused on the problems existing in the current experimental courses of medical microbiology, introduced the basic method and implementation effect of using a flipped classroom based on microlectures. Compared with the traditional teaching methods, the reformed teaching method could improve the teaching quality significantly, thus providing useful experience for the reform of other basic medical courses in our university.