Abstract:In recent years, the relationship between gut flora and psychiatric disorders such as autism spectrum disorder, anxiety, depression, has gained increasing attention. This article mainly introduced the correlation between gut flora and depression, and the existing evidence that whether and how the probiotics might affect depression. Although exciting progress has been achieved in this area, further studies are still needed to promote our understanding about the causality between gut flora and depression, and to fully assess the potential of probiotics to prevent and treat depression.