鸡马立克病毒的研究进展

Progress in Marek’s disease virus

摘要:

马立克病毒(Marek’s disease virus，MDV)是一类可感染鸡诱发急性或亚急性淋巴细胞肉瘤的疱疹病毒。本文在对MDV的经典病毒学及分子生物学研究的早期成果进行概述的基础上，对近十多年来感染性克隆技术用于探索MDV主要蛋白基因的功能、以病毒编码的全部蛋白质为对象的蛋白组学、病毒编码的有调控作用的RNA及基因工程疫苗等方面的研究进展进行综述，并展望MDV进一步的研究方向和内容。

关键词:马立克病毒，感染性克隆，蛋白组学，调控性RNA，重组疫苗

Abstract:

Marek’s disease viruses (MDV) is a group of important herpesviruses, which can induce acute or sub-acute immunosuppressive and neoplastic disease in chickens, namely Marek’s disease (MD). Based on a brief overview of early studies on the classical and molecular virology of MDV, the progresses in the last decade are reviewed in different aspects, such as the application of the technique of infectious bacterial chromosome clone (BAC) to study viral gene functions, the studies on proteomics of MDV protein-coding genes, the regulatory functions of virus-encoded non-coding RNAs, and the recombinant MDV vaccines. Furthermore, the expected subjects or aspects for the further study on MDV are also discussed.

Key words:Marek’s disease viruses, infectious clones, proteomics, regulationg RNA, recombinant vaccines