双功能乙醛/乙醇脱氢酶AdhE参与细菌与宿主互作的机制研究进展

Regulatory mechanisms of aldehyde/alcohol dehydrogenase in bacteria-host interactions

摘要:

双功能乙醛/乙醇脱氢酶AdhE具有乙醛脱氢酶和乙醇脱氢酶的催化活性，是细菌乙醇厌氧发酵途径中的关键酶之一。近年，有关细菌与宿主相互作用的研究表明，AdhE在细菌适应宿主内环境变化和发挥毒力时具有重要的调控作用。本文对AdhE参与调控细菌感染宿主的致病机制和参与细菌对宿主免疫功能调节的作用机制进行综述，以期为AdhE的功能研究提供新的思路。

Abstract:

The bifunctional aldehyde/ethanol dehydrogenase (AdhE) exhibits acetaldehyde dehydrogenase (ALDH) and alcohol dehydrogenase (ADH) activities, and is one of the key enzymes in the bacterial ethanol anaerobic fermentation pathway. Researches on bacteria-host interactions revealed that AdhE also plays an important role in bacteria adapting to the internal environment changes and regulating bacterial virulence. In this paper, we summarized the regulatory mechanisms of AdhE on bacterial pathogenesis and host immune, which may provide new perspectives for understanding AdhE’s function.