Abstract:Accumulating literatures indicate that intestinal microflora, known as the second human genome, can affect glycolipid metabolism, and then regulate the corresponding diseases. In this review, we introduce the distribution, species and influencing factors of intestinal microflora. We mainly address the relationship between intestinal microflora and glycolipid metabolic diseases, and the mechanism how intestinal microflora regulates the glycolipid metabolism. Moreover, the potential use of glycolipid metabolism for clinical diagnosis and treatment of diseases is also discussed.