基因工程菌生产抗菌肽的研究进展

Progress in engineering bacteria producing antibacterial peptides

摘要:

目前，利用基因工程菌生产抗菌肽，提供有效和稳定的方法是抗菌肽生产的热点之一。了解抗菌肽工程菌表达系统、生产量尤为重要，为此本文阐述了抗菌肽的生产方式，介绍了基因工程菌表达系统的种类、组成及特点，分析了基因工程菌生产抗菌肽的主要困难因素，并对近些年利用基因工程菌生产抗菌肽的进展进行了综述。

Abstract:

Recently, it is the one of the hot topic for antimicrobial peptides (AMPs) to be produced using recombinant expression system with efficiency and stable protocols. It is particularly crucial for us to know different expression systems we use and their production. For this purpose, we narrate methods to produce AMPs, species, elements and properties of different expression systems, mainly there is an analysis for some difficult factors to construct engineered bacteria. And, we also reviewed the progress of producing antibacterial peptides using engineered bacteria in recent years.