Abstract:Basic helix-loop-helix (bHLH) proteins belonging to a superfamily of transcription factors, are widely distributed in eukaryotic organisms. Members of this protein family can form homodimers or heterodimers, and then bind to E-box motifs to uniquely affect the transcription of genes. The bHLH transcription factors are widely involved in developmental processes, including cellular proliferation and differentiation. Therefore, they often play a very important role in regulating growth, development, and differentiation in eukaryotes. Here, we review the regulation process and biological function of bHLHs in Aspergillus species including Aspergillus nidulans, Aspergillus fumigatus, and Aspergillus oryzae, to provide a theoretical reference for further study on the growth and development of Aspergillus and functions of bHLHs.
