环境中抗生素抗性基因与I型整合子的研究进展

Antibiotic resistance genes and class 1 integron in the environment: research progress

摘要:

抗生素抗性基因(Antibiotic resistance genes，ARGs)作为一种新型污染物在不同环境中广泛分布、来源复杂，对生态环境和人类健康造成了很大的潜在风险。同时，I型整合子(Int I)介导的ARGs水平转移是环境中微生物产生耐药性的重要途径，I型整合子整合酶基因(intI1)与ARGs丰度在环境中表现出了较高的正相关性，Int I可以作为标记物在一定程度上反映ARGs在环境中的迁移转化规律和人类活动影响程度。本文介绍ARGs与Int I在环境中的来源与分布，总结Int I介导的ARGs迁移转化机制以及相关研究方法，并展望未来的研究发展趋势。

Abstract:

As a new type of pollutant, antibiotic resistance genes (ARGs) come from complicated sources and distribute widely in different habitats to pose a great potential risk to ecological environment and human health. Meanwhile, class 1 integron plays an important role in ARGs horizontal transfer among environmental bacteria and turns them into antibiotic resistant bacteria (ARB). The abundance of intI1 and ARGs in the environment shows a significant positive-correlation, therefore Int I might be used as a molecular marker to indicate the mechanism of ARGs transfer and transformation in the environment and reflect the impact of human activities. In this paper, we introduce the sources and distribution of ARGs and Int I in the environment, review the dissemination mechanisms of ARGs via Int I and related research methods, and predict the future research trends based on the current research progress.