Abstract:English taught courses for undergraduate students have achieved rapid development in domestic universities. Microbiology is a professional compulsory course with international universality, and more and more universities implement all-English to deliver the course currently. However, there still exist some problems for English taught courses such as, language barriers to free communication and total understanding, imperfect evaluation system and so on. In order to address these problems and facilitate the sound development of English taught course for Microbiology, we proposed to exploit a blended “bilingual teaching+ Massive open online courses (MOOC) sharing course” teaching mode, which is in line with the characteristics of Chinese students, and can be used to overcome the difficulties faced by teachers and students in the teaching process of microbiology.