寨卡病毒蛋白结构与功能研究进展

Research progress on the structure and function of Zika virus proteins

摘要:

2015年以来，南美暴发大规模寨卡疫情，因其与新生儿小头症等严重神经发育疾病密切相关，被世界卫生组织列为国际关注的突发公共卫生事件。与其他虫媒黄病毒类似，寨卡病毒为单股正链RNA病毒，其基因组编码的3种结构蛋白构成病毒颗粒，7种非结构蛋白参与病毒复制生活周期的调控。在全球科学家的共同努力下，寨卡病毒蛋白结构与功能的研究取得了突破性进展，极大地促进研究者对病毒复制与致病机制的认识，也为疫苗和药物研发提供了重要科学依据和潜在靶标。本文将对寨卡病毒蛋白的结构与功能的最新研究进展作一综述，并讨论当前面临的挑战和机遇。

Abstract:

The largest Zika virus (ZIKV) outbreak in South America in 2015 raised considerable worldwide health concern, owning to its unexpected link to microcephaly in the newborns and Guillain-Barré syndrome in adults. The WHO has declared the outbreak a global public health emergency. Currently no vaccines and therapeutics are available. The analysis of the crystal structure of ZIKV and viral proteins will deepen the understanding of viral replication and pathogenesis, which provides important targets for the development of vaccines and drugs. Here, we review the latest advances in research on the structural biology of ZIKV and viral proteins.