1. Anhui Medical University, Hefei, Anhui 230032, China; 2. State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China 在期刊界中查找 在百度中查找 在本站中查找
1. Anhui Medical University, Hefei, Anhui 230032, China; 2. State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China 在期刊界中查找 在百度中查找 在本站中查找
1. Anhui Medical University, Hefei, Anhui 230032, China; 2. State Key Laboratory of Pathogen and Biosecurity, Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing 100071, China 在期刊界中查找 在百度中查找 在本站中查找
The largest Zika virus (ZIKV) outbreak in South America in 2015 raised considerable worldwide health concern, owning to its unexpected link to microcephaly in the newborns and Guillain-Barré syndrome in adults. The WHO has declared the outbreak a global public health emergency. Currently no vaccines and therapeutics are available. The analysis of the crystal structure of ZIKV and viral proteins will deepen the understanding of viral replication and pathogenesis, which provides important targets for the development of vaccines and drugs. Here, we review the latest advances in research on the structural biology of ZIKV and viral proteins.
