翻译延伸因子EF-P的结构和功能及其研究进展

Progress in studies on structure and function of elongation factor P

摘要:

EF-P (Elongation factor P)是普遍存在于细菌中的蛋白质翻译延伸因子，因其L型结构与tRNA类似，可挽救聚脯氨酸导致的翻译延宕，减缓核糖体的失速效应。EF-P虽然不是细菌生存的必需蛋白，但是对细菌自身的环境适应性以及一些致病菌的毒性维持至关重要。本文综述了细菌EF-P的结构、功能及其相关研究进展。

Abstract:

EF-P (Elongation factor P) is a translation elongation factor commonly conserved in bacteria. Due to its L-shaped structure similar to tRNA, EF-P can rescue stalled ribosome caused by polyproline. Although it is not an essential protein in bacteria, it is crucial for bacterial fitness and virulence of some pathogens. In this paper, the structure, function and related research progress of bacterial EF-P are reviewed.