Abstract:The open classroom based on modern network technology is the product of the development of the information age, which is a useful supplement to the existing teaching methods and the future direction of development. We introduced the concept of modern open class, including the flip classroom, and explore the training mode of innovative and entrepreneurial talents, so as to solve the problems of lack of creative enthusiasm, less interaction between teachers and students, and low success rate of experiments. By the simulation experiment platform, mobile classroom, flip classroom, online laboratory, network broadcast and other interactive mode of a variety of novel and vivid as the carrier, the open classroom teaching through the college students’ innovation and entrepreneurship process, enrich the teaching resources and teaching methods. To maximize the interaction between teachers and students, stimulate students’ innovative enthusiasm, cultivate students’ entrepreneurial personality, enhance students’ ability to grasp opportunities and the ability to use innovative thinking.