关于组学大数据背景下《微生物学》教材框架的思考

The theoretical considerations about the framework of Microbiology in the era of big data

摘要:

微生物学是生物学的重要内容，是全国高等院校生物学专业或相关专业的本科生必修的一门核心基础课，其主要任务是给学生提供基础的、系统的、前沿的微生物学知识和理论。随着高通量测序、质谱、芯片等高通量技术的快速发展，生命科学领域快速进入了以海量多元组学(基因组学、转录组学、蛋白质组学、免疫组学、代谢组学等)数据为特征的大数据时代，而这势必会对微生物学教材已有的内容产生冲击和补充。本文对如何在组学大数据背景下对国内经典的微生物学教材进行改革，将目前最具突破性的组学成果整合到已有的教材框架中或革新现有教材框架进行了初步探讨。

Abstract:

Microbiology, an important branch of biology, is the required core course for Biology or related undergraduates in university, aiming to provide basic, systematic and cutting-edge microbiology knowledge for students. With the development of high-throughput sequencing, mass spectrometry and chip technology, life sciences evolved into the era of big data with enormous multiple omics (genomics, transcriptome, proteomics, immune omics and metabolomics etc.), which presented great challenge for the content or frame of microbiology. In this paper, we discussed how to reform the domestic classical microbiology teaching material within the context of big data, and how to integrate the omics into the current framework of teaching material or reform new teaching material framework.