CRISPR-Cas系统调控细菌生理功能的机制研究进展

Advances in the mechanism of CRISPR-Cas system for regulating bacterial physiological function

摘要:

CRISPR-Cas系统是存在于部分细菌和绝大部分古细菌中的一种获得性免疫防御系统，使细菌在外源性基因入侵时具有免疫防御能力。此外，CRISPR-Cas系统对细菌自身生物膜的形成、耐药性、毒力等生理功能都有调控作用，这对于研究人员进行相关研究有着重要意义。本文以细菌CRISPR-Cas系统及其发挥免疫防御作用的相关研究为基础展开论述，重点阐述该系统对细菌生理功能的调控作用，并对其应用前景进行了展望，以期为进一步研究细菌耐药性和致病性提供新思路。

Abstract:

CRISPR-Cas system is an acquired immune defense system that is found in some bacteria and most of the ancient bacteria. It makes the bacteria immune defense against the invasion of exogenous genes. In addition, CRISPR-Cas system plays a regulatory role in the formation of bacterial biofilm, drug resistance, virulence and other physiological functions, as well as in scientific research. According to this, we discussed the bacterial CRISPR-Cas system and its related research on the immune defense. Moreover, we described the regulatory function of this system in physiological function of bacterial and its future application, to provide a new idea for further study on bacterial resistance and pathogenicity.