猪塞尼卡谷病毒流行态势与诊断防控研究进展

Advance in Seneca valley virus epidemiology, diagnosis and control

摘要:

塞尼卡谷病毒(Seneca valley virus，SVV)为小RNA病毒科塞尼卡病毒属的唯一成员， 2002年首次发现于PER.C6细胞培养物中，被鉴定为细胞培养基中的污染物。最初SVV被用作溶瘤病毒进行肿瘤治疗研究。现已证实SVV感染猪能够引发原发性水泡病，引起猪的鼻吻、蹄部冠状带的水泡病变，同时伴有跛行、厌食、嗜睡和发烧等临床表现。与口蹄疫、猪水泡病和水泡性口炎引起的临床症状难以区分。2015-2017年期间，在美国、中国、泰国等多个国家暴发了SVV疫情，并且流行范围逐步扩大。针对该病的不断扩散，急需提出和制定有效的诊断与防控策略及措施。因此，一些新的诊断方法被不断开发出来，新的防控策略也在逐步建立。本文主要针对SVV最新的流行态势及特点、诊断与防控技术进行综述，旨在提供SVV最新研究进展，提高疾病防控及科研工作人员对该病的进一步认识和了解，为该病的防控提供理论依据和参考。

Abstract:

Seneca valley virus (SVV) belongs to Senecavirus genus of family Picornaviridae, and is classified as the unique member of Senecavirus genus. SVV was identified in 2002 while cultivating viral vectors in PER.C6 cell culture and was suggested to be contaminated by fetal bovine serum or porcine trypsin. Many studies about SVV at the initial time have focused on the potential oncolytic activity of SVV in human cancer therapy. It is now identified as a pathogen to infect pigs and cause porcine idiopathic vesicular disease. The clinical signs include: cutaneous vesicular lesions on the snout and coronary bands, lameness, anorexia, lethargy and fever. These clinical signs are similar with that caused by foot-and-mouth disease, swine vesicular disease and vesicular stomatitis. Therefore, these diseases are indistinguishable by clinical signs. In 2015 to 2017, SVV infection occurred in the United States, China, Thailand and many other countries, with increasing spread and outbreaks. Therefore, urgent surveillance and control policies are needed to limit the spread of SVV. Several new diagnostic and control methods have been exploited. In the present review, we summarized the recent spread information, diagnostic and control methods of SVV to provide theoretical foundation for controlling of this disease.