密度感应系统：对细菌致病力的自行调控

Quorum sensing: an auto regulator for bacterial pathogenicity

摘要:

细菌通过密度感应系统感受环境中的信号分子，进而调控菌群一系列生物学性状。研究发现密度感应系统能够调控细菌生物被膜形成、毒力基因表达及噬菌体感染等功能，其中基于密度感应系统调控细菌抵御噬菌体感染更是新发现，预期也将是未来数年的研究热点，其调控机制的阐明将为有效应用噬菌体开展耐药菌的防控展现广阔前景。本文将重点综述细菌密度感应系统对细菌致病相关功能的调控机制，旨在为病原菌的防控提供新思路。

Abstract:

Bacteria could sense the signal molecules and regulate their physiological behavior via quorum sensing (QS). QS is involved in the regulation of biofilm formation, virulent genes expression as well as the phages infection. QS could control adaptive immunity through the regulation of CRISPR-Cas systems, which is the latest finding and presumed to be the highlight in the near future. To elucidate its regulating mechanisms and reveal broad prospect for bacterial therapy by phage, we reviewed QS regulating mechanisms on bacterial pathogenicity for the control of pathogenic bacteria.