Abstract:Classical swine fever (CSF) caused by classical swine fever virus (CSFV), is a highly contagious disease of swine that is characterized by hemorrhage syndrome and immunosuppression. It is one of the most important swine diseases worldwide and leads to significant economic loss in the pig industry in China and other regions of the world. Studies have shown that infection with CSFV can induce host innate immune response, but this virus can suppress the host innate immunity through influencing the expression of effector molecules of the innate immune system. In this review, we highlight the current understanding of host innate immune response and immune suppression during CSFV infection. In addition, we review the mechanisms by which CSFV infection induces innate immunity and its suppression.