科微学术

微生物学通报

猪瘟病毒与宿主天然免疫系统的相互作用
作者:
作者单位:

作者简介:

通讯作者:

中图分类号:

基金项目:

国家自然科学基金项目(No. U1405216,31402217);国家重点基础研究发展规划(973计划)项目(No. 2015CB910502)


Interaction between classical swine fever virus and host innate immune system
Author:
Affiliation:

Fund Project:

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    猪瘟(Classical swine fever,CSF)是由猪瘟病毒(Classical swine fever virus,CSFV)感染引起的一种高度接触性传染病,临床上以出血综合征与免疫抑制为主要特征。它在多个国家流行,给中国乃至世界养猪业造成巨大的经济损失。研究表明,猪瘟病毒感染能够诱导宿主的天然免疫应答,也能通过影响天然免疫效应分子的表达来抑制宿主的天然免疫功能。本文将对猪瘟病毒感染与天然免疫应答及其免疫抑制的现象与机理进行综述。

    Abstract:

    Classical swine fever (CSF) caused by classical swine fever virus (CSFV), is a highly contagious disease of swine that is characterized by hemorrhage syndrome and immunosuppression. It is one of the most important swine diseases worldwide and leads to significant economic loss in the pig industry in China and other regions of the world. Studies have shown that infection with CSFV can induce host innate immune response, but this virus can suppress the host innate immunity through influencing the expression of effector molecules of the innate immune system. In this review, we highlight the current understanding of host innate immune response and immune suppression during CSFV infection. In addition, we review the mechanisms by which CSFV infection induces innate immunity and its suppression.

    参考文献
    相似文献
    引证文献
引用本文

蔡彬祥,於子鼎,曾显成,池晓娟,陈吉龙. 猪瘟病毒与宿主天然免疫系统的相互作用[J]. 微生物学通报, 2017, 44(12): 2997-3006

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2017-12-05
  • 出版日期: