Abstract:In the early, the researchers had explored the symbiotic mechanisms of lactic acid bacteria and yeasts from the perspectives of nutrition. In the process of mixed culture, there are not only complementary mechanism, but also can promote or inhibit each other. As the LuxS/AI-2 mediated quorum sensing system (QS) of the discovery and development, a lot of researchers from the perspective of quorum sensing system to explore the information of communicate between lactic acid bacteria and yeasts at present. This article has elaborated the current research progress of symbiotic mechanism of lactic acid bacteria and yeasts from two perspectives of nutrition and signaling molecules.