Citrinin is a nephrotoxicity fungal metabolite produced by several fungi of the genera Penicillium, Aspergillus and Monascus, and contaminates food and feed. Citrinin synergistically combines with other mycotoxins, such as patulin and ochratoxin to cause great harm to human and animal health. This article reviews the scope of citrinin toxicity and the progress of different methods to control citrinin in food and feed.