乳酸杆菌S-层蛋白的特性及功能性研究进展

Research progress on the features and functions of Lactobacillus S-layer protein

摘要:

文章综述了S-层蛋白的性质和功能，重点介绍了S-层蛋白对乳酸杆菌表面性质和黏附性的影响以及调节肠道功能的作用，包括减少病原菌引起的细胞凋亡、调节免疫细胞的活性、与SIGNR3相互作用参与肠道免疫反应、通过TLRS-MyD88-NF-κB途径发挥生物学功能以及调控肠道黏膜相关蛋白表达。由此证明了S-层蛋白对于乳酸杆菌发挥免疫调节功能具有重要的作用。

Abstract:

In this paper, the properties and functions of Lactobacillus S-layer protein were reviewed. The effects of S-layer protein on surface-properties, adhesion capacities of Lactobacillus bacteria and the regulation of intestinal function are also introduced, including reducing apoptosis caused by pathogenic bacteria, immunoregulating cell activity, participating in the intestinal immune response through the interaction with SIGNR3, exerting biological function through TLRS-MyD88-NF-κB pathway and regulating expression of intestinal mucosa associated proteins. Thus demonstrated that S-layer protein plays an important role in the function of immunoregulatory effect.