原核生物蛋白O-糖基化的研究进展

Research progress of protein O-glycosylation in prokaryotes

摘要:

自从在原核生物中发现蛋白糖基化之后，越来越多的O-糖基化机制在不同种属的细菌中被发现。本文根据对O-寡糖基转移酶(O-oligosaccharide transferase，OTase)的依赖与否，将原核生物的O-糖基化分为OTase非依赖型和OTase依赖型，并分别对这两种糖基化机制进行了详细阐述。通过对不同的O-糖基化机制的深入了解，为以后更好地利用这些途径来合成工程化的目标糖蛋白奠定基础。

Abstract:

Since protein glycosylation was found in prokaryotes, multiple O-glycosylation mechanisms in the bacteria from varied genera have been reported. According to the requirement of O-oligosaccharyltransferase (OTase), the O-glycosylation in prokaryotes was divided into OTase-independent and OTase-dependent. Furthermore, the two glycosylation mechanisms were elucidated in detail. The insight into various O-glycosylation mechanisms in prokaryotes would facilitate the application of these pathways to explore targeted glycoproteins.