Abstract:Compared to traditional processing method of minerals, bioleaching is low-cost, easy-operating and low pollutioned and has began to be applied in the treatment of refractory gold ore, low-grade minerals or high-sulfur coal. To make full use of the synergy of leaching bacteria, the present work mainly addressed the synergic advantage and problems during bioleaching comprehensively and the predicted the bioleaching trend in the future. Firstly, the biological characteristics of three important leaching bacteria were analyzed, including Acidithiobacillus ferrooxidans, Leptospifillum ferrooxidans and Acidithiobacillus thiooxidans. Secondly, domestic and abroad research development of bioleaching and its synergic mechanism were also discussed. Finally, possible research prospect and solution of bioleaching technology in two decades was predicted.