细菌II型毒素-抗毒素系统活性的调控

Regulation of activity of II-type toxin-antitoxin systems in bacteria

摘要:

细菌毒素-抗毒素系统(Toxin-antitoxin system，TA)由稳定的毒素和不稳定的抗毒素构成，几乎存在于所有细菌中。已证明染色体编码的II型TA系统作为胁迫反应因子，通过毒素作用于不同的细胞靶点来调控重要的细胞活动过程，使细菌适应不同的环境胁迫。因此，毒素活性的调控是II型TA系统介导细菌适应性胁迫反应的关键。本文总结了II型TA系统毒素活性调控机制的研究进展，并介绍了作者近年来对模式蓝藻Synechocystis sp. PCC6803中II型TA毒素活性调控的研究结果。

Abstract:

Bacterial toxin-antitoxin (TA) systems are formed by a stable toxin and its cognate labile antitoxin, and exist almost in all bacteria. Recently, the chromosome-encoded II-type TA systems have been demonstrated to function as stress-response elements and help bacteria acclimate to different environmental stresses through the action of toxins to various cellular targets. Therefore, the modulation of toxin activities is crucial to II-type TA systems triggering bacterial response to environmental stresses. In this review, we describe the regulation mechanisms of II-type TA system activity, and briefly introduce our recent studies on the regulation of the II-type TA systems in the model cyanobacterium Synecocystis sp. PCC6803.