生物法转化甘油生产1,3-二羟基丙酮的研究进展

Research progress on the production of 1,3-Dihydroxyacetone by biotransformation

摘要:

1,3-二羟基丙酮(DHA)是一种重要的化工医药中间体，广泛应用于化妆品、医药和食品等领域，开展提高DHA生产效能的研究对于工业生产具有指导意义。甘油生物转化生产DHA是目前主要的工业生产方法，但存在菌株转化效能有待提高、底物和产物抑制、溶氧限制等问题。本文概述了DHA的生物合成途径、菌株改良策略、生产工艺及分离提取等方面的研究进展，指出利用代谢工程技术改造菌种、优化生产工艺、简化分离提纯方法是今后的研究方向。

Abstract:

1,3-dihydroxyacetone (DHA) is a kind of important chemical raw materials and pharmaceutical intermediates. It is widely used in cosmetics, pharmaceutical, food and other fields. Therefore, it is important to carry out studies on the production of DHA. Biotransformation of glycerol to DHA is the main method for industrial production of DHA. However, there exists substrate and product inhibition, and dissolved oxygen limitation during the production process. In this paper, the progress of DHA biosynthetic pathway, strain improvement, common production process, separation and extraction methods are summarized. In order to improve the strain productivity, it is important to optimize the metabolic pathway and production process, simplify the separation and purification routes in the future.