With the development of mobile technology and the popularization of the network, the use of mobile terminal for the study of micro course will become a new way of learning. This paper attempts to utilize WeChat public platform for micro mobile course of Medical Microbiology, and takes advantage of dispersive time to conduct mobile teaching,in order to compensate the inadequacy of traditional classroom teaching. It evaluates the teaching effect, advantages and existing problems of the WeChat public platform in micro medical microbiology course. It further illuminates the broad prospects of micro mobile course of medical microbiology based on WeChat public platform.