Abstract:In view of the fact that medical laboratory specialty in higher vocational college recruit students from arts and science currently and combined with students’ weak foundation, in course teaching of microbiological examination, led by microbiological testing job tasks as well as reinforcement of skills training, the curriculum has designed four modules, basics, basic skills, technology applications and unit training namely, fusing the theoretical knowledge of microorganism to skills training programs, to build “Serial Architecture” course architecture. Part of the experiment is designed by students themselves, with various measures teaching methods and diversified assessment methods. The results show that: curriculum reform and practice has stimulated students’ interest in learning and cultivated the students’ creative ability and practical ability, with obvious teaching effects.