金黄色葡萄球菌非编码小RNA的研究进展

Small non-coding RNAs in Staphylococcus aureus-a review

摘要:

金黄色葡萄球菌(Staphylococcus aureus，S. aureus)是困扰全球公共卫生及人类健康的重要病原菌，其引起的各种临床感染与该菌表达的多种毒力因子密切相关，而这些毒力因子表达受到调节性因子的精确调控，在细菌致病机制中发挥着核心作用。非编码小RNA (Small non-coding RNA,sRNA)是基因表达的一类重要调节因子，可使细菌对环境因素做出反应，调节其应激适应性及毒力因子表达。但到目前为止，仅少数金黄色葡萄球菌sRNA的生物学功能得到阐述。本文将针对这些调节性sRNA的研究进展作一综述。

Abstract:

Staphylococcus aureus is a leading pathogen threatening global public health. Various clinical infections caused by S. aureus are closely related to the expression of many virulence factors. The expression of these virulence factors is precisely regulated by regulatory factors, which have the key role in the pathogenicity of S. aureus. Small non-coding RNAs (sRNAs) are important regulatory factors, which can make S. aureus respond to environmental changes, and regulate the stress and expression of virulence. However, biological functions have only been elucidated for a few of these sRNAs. In this review, we summarize the recent research progress in S. aureus regulatory sRNAs.