益生菌通过调整正常菌群缓解酒精性肝损伤的研究进展

Ameliorating alcoholic liver injury by adjusting intestinal flora with probiotics

摘要:

许多临床试验表明慢性酒精性肝损伤会引起肠道菌群的失调，主要表现为双歧杆菌、乳杆菌数量减少，革兰氏阴性菌大量繁殖，破坏肠道屏障功能，增加肠道通透性，使细菌来源的内毒素大量释放出来，引起血液内毒素增加，并在肝脏中累积，超出肝脏的清除能力，导致肝损伤。本文主要综述益生菌通过调整正常菌群这一机制来缓解酒精性肝损伤的研究进展，进而深入了解酒精引起肠道菌群变化(酒精的摄入会导致肠道中拟杆菌、厚壁菌数量减少，革兰氏阴性变形菌、革兰氏阳性放线菌数量增加，同时肠道内细菌来源的内毒素水平增加)导致肝损伤的发病机制，以及益生菌如何通过调整肠道正常菌群改善酒精性肝损伤。

Abstract:

Many clinical trials showed that chronic alcohol leads to imbalance of intestinal flora which is characterized by the decrease of Bifidobacterium and Lactobacillus, with a proportional increase of gram-negative bacteria. Alcohol causes the destruction of intestinal barrier function, increases intestinal permeability, releases bacteria endotoxins, and causes liver damage. This paper reviews the research progress in using probiotics to repair alcoholic liver injury by adjusting the intestinal flora and improving intestinal barrier function.