裂解酶治疗的研究进展与应用前景

Research progress in lysin therapy

摘要:

多耐药病原细菌的不断出现和传播给公共医疗造成了严峻的威胁和挑战，开发新的抗菌分子迫在眉睫。噬菌体裂解酶来源于噬菌体，具有独特的进化和选择优势，不仅能高效快速的杀灭多耐药细菌，而且不易诱导细菌产生新的耐药性。本文对噬菌体裂解酶的结构和功能进行了简要的介绍，重点综述了裂解酶在抗细菌感染中近年的研究进展和应用前景。

Abstract:

Treating infections caused by multi-drug resistant pathogenic bacteria is a challenge worldwide. It is critical to develop novel antimicrobial agents. Lysins are highly efficient peptidoglycan hydrolases which are encoded by bacteriophages. Because of their special advantages of co-evolution with bacteria and natural selectivity, lysins could kill multi-drug resistant bacteria with high efficacy and very low possibility of developing resistance. In the present review, the structures and functions of lysins are outlined, and the recent research progress in lysin therapy of bacterial infections is summarized.