Abstract:Cordyceps is precious Traditional Chinese Medicine, having a wide range of pharmacological effects such as anti-cancer, anti-bacterial, immune regulation, lowering blood lipid, lowering blood sugar, etc. Selenium is an essential trace element, which has broad physiological functions including anti-cancer, anti-oxidation, anti-aging, etc. and closely associated with a variety of diseases. Combinating Cordyceps fungus and Selenium to produce Selenium-enriched Cordyceps has important significance as medicine, health care products and food Selenium supplementation. This article gives a review on Selenium-enriched Cordyceps research in the past 20 years.