Abstract:Plant wilt is one of disease difficult control caused by Fusarium oxysporum in crop and vegetables production field. Here is a review about domestic and overseas studies on pathogenesis by F. oxysporum and the application of allelopathic. Co-pathogenesis caused by F. oxysporum secretion of toxins and cell wall degrading enzymes in host plants. The lineage-specific region is the reason of F. oxyspoyum with strongly virulent and widely host. Different genes associated with its disease mechanisms have been isolated respectively in specialized F. oxysporum strains. However, some plants and microorganism (Trichoderma spp., arbuscular mycorrhizal fungi, non-pathogenic F. oxysporum, and plant growth promoting rhizobacteria) release allelochemicals which directly inhibit the growth of F. oxysporum or active defense reaction of host plants. For the furthermore in future, genome sequencing will be essential for building accurate genetic maps of different pathotypes of F. oxysporum. And gene-gene relationships between F. oxysporum and the resistance host plant should be exploded. High-throughput technologies will be necessary at the level of transcriptome as well as at the proteome level. Screening new plant varieties for resistance blight will also be developed by molecular marker assisted breeding.