白念珠菌胞内铁离子存储转运系统的研究进展

Research advances of cellular iron transport and storage in Candida albicans

摘要:

白念珠菌是一种常见的条件致病性真菌。为了在宿主体内复杂的铁离子微环境中定居、生长和繁殖，该菌在长期的进化过程中演化出一系列复杂的铁离子稳态调控网络，包括位于细胞膜表面的铁离子吸收系统和位于细胞内的铁离子储存、转运及利用系统。本文结合课题组研究工作，简要综述近几年关于铁离子吸收、储存及转运机制的研究进展，主要关注细胞内铁离子的储存、转运，尤其是线粒体在胞内铁离子代谢及稳态维持方面的作用。

Abstract:

Candida albicans is one of the most important opportunistic pathogens. In order to adapt to the various ecological niches of the host, Candida albicans has evolved a variety of sophisticated metabolic strategies to maintain iron homeostasis, including multiple iron acquisition systems that target the cell membranes, and the mechanisms that coordinate intracellular iron trafficking. Here, combined with our study, we review the research advances of iron acquisition, storage and transportation strategies in recent years, focusing on intracellular iron storage and transport, especially the roles of mitochondria in cellular iron metabolism and homeostasis.