Abstract:Ubiquitination, as a regulating mechanism of cell reactions, exists extensively in plant and is involved in regulating plant disease resistance. This paper reviewed the function and mechanism of ubiquitination system in regulating plant disease resistance. Particularly, we mainly introduced how CRLs and RING/U-box type E3 ubiquitin ligases mediate plant disease resistance signaling and the molecular mechanism of regulation in plant disease resistance through effectors and virulent factors of pathogens. This paper provides reference for illustrating the mechanism of plant disease resistance and controlling the plant diseases.