Abstract:Water Treatment Microbiology is an important specialized foundation curriculum in applied chemistry profession. In order to meet the training needs of excellent engineers education program, Water Treatment Microbiology curriculum was reformed and practiced in four aspects containing the formulation of teaching program, optimization of teaching content, reformation of teaching methods and means and construction of curriculum examination evaluation system according to existing problems in the teaching. The results indicated that the engineering practices and innovative capability of students were increased and the comprehensive quality of students was improved based on the curriculum reformation and practice, which could lay a foundation for the successful training of excellent engineers.