幽门螺杆菌抗生素耐药机制研究进展

Progress in research on antibiotic resistance mechanisms of Helicobacter pylori

摘要:

幽门螺杆菌(Helicobacter pylori，H. pylori)感染可引起消化性溃疡、胃粘膜相关淋巴组织淋巴瘤和胃癌。随着抗生素耐药性的问题越来越严重，耐药机制的研究也不断深入。分子检测方法，尤其是核酸检测技术，可高效、快速、准确地检测幽门螺杆菌抗生素耐药基因及突变，对幽门螺杆菌感染的临床治疗发挥重要的指导作用，同时也可对幽门螺杆菌抗生素耐药性进行大规模及时有效监控。本文讨论了关于幽门螺杆菌抗生素耐药机制并着重总结了相关耐药基因及突变。

Abstract:

Helicobacter pylori (H. pylori) infection can cause peptic ulcer disease, gastric mucosa associated lymphoid tissue lymphoma (GMALTL) and even gastric cancer. With increasing problem of antibiotic resistance, study on mechanisms of which is promoted deeply. Molecular detection methods, especially the nucleic acid detection technologies, can be used to detect antibiotic resistance genes or mutations efficiently, rapidly and accurately, hence guiding the clinical treatment of H. pylori infection and helping to investigate antibiotic resistance rate timely and effectively in a large area. In this review, H. pylori antibiotic resistance mechanisms of the most commonly used antibiotics were discussed and associated resistance genes or mutations were emphatically reviewed.