国内酿酒酵母分子遗传与育种研究40年

Research progress of molecular genetics and breeding of Saccharomyces cerevisiae in China in the past 40 years

摘要:

酿酒酵母作为最简单的真核生物，是研究真核生物基本生命规律的重要模式系统，也是生物产业领域非常重要的微生物细胞工厂。在《微生物学通报》创刊40周年之际，本文综述了国内40年来在酿酒酵母分子遗传学与育种研究的重要进展，如分子遗传学研究手段的建立、重要功能基因的分析、重要生命过程的遗传基础和调控机制，以及酵母菌育种技术的建立与应用等。

Abstract:

As a unicellular organism, Saccharomyces cerevisiae is an ideal model system for illumination of substantial cellular functions of eukaryotes. Meanwhile, this organism is also an important microbial cell factory in biotechnology. On the occasion of the 40th anniversary of the magazine Microbiology China, the research advances of molecular genetics and breeding of S. cerevisiae in china in the past 40 years, such as tools for genetic manipulation, functional analysis of specific genes, the genetic basis and regulatory mechanism underlying the important biological processes, development and application of breeding approaches, were reviewed here.