Recently, harmful algae blooms (HABs) always frequently outbreaks on eutrophication water body and it has been recognized as a serious worldwide environmental problem. It is very important and useful method that algae-lysing microorganisms as biocontrol agents to control HABs and to purify to water. This article reviews on microbial to control harmful algal blooms and discuses application prospect in the future. In additionally, the results are expected to have a certain reference value for researching algae lysing and application in other aspects.