非核糖体肽合成酶催化的非常规装配模式

Unconventional assembling ways catalyzed by nonribosomal peptide synthetases

摘要:

非核糖体肽合成酶(NRPSs)催化形成复杂肽类天然产物, 其中很多显示了很好的生物学活性和医疗价值。常规NRPSs具有模块化和线性催化的特点, 然而在生物合成研究过程中也发现了很多具有非常规装配模式的NRPSs。本文针对其中4种非常规装配模式: 重复使用、非线性、模块跳跃和非核糖体前肽模式, 结合一些代表性例子做一小型综述。

Abstract:

Nonribosomal peptide synthetases (NRPSs) catalyze the formation of complex peptide natural products, of which many display therapeutically useful activity. Conventional NRPSs have been characterized as modular and co-linear assembling. Recent studies of many NRPS systems revealed some examples where the catalytic logic does not directly correspond to the linear arrangement of modules and domains. This mini review summarizes the recently discovered NRPS biosynthetic pathways focused on four types of unconventional assembling ways including iterative NRPSs, nonlinear NRPSs, module skipping NRPSs and the nonribo-somal propeptide biosynthetic mode.