猪链球菌2型89K毒力岛研究进展

Research progress on 89K pathogenicity island of Streptococcus suis serotype 2

摘要:

高致病性猪链球菌2型的致病机制仍是未解之谜。毒力岛不仅赋予病原菌特殊的致病能力, 而且在细菌的适应性进化过程中扮演重要角色。对猪链球菌2型89K毒力岛功能性基因的深入剖析有助于更全面地掌握病原菌的致病特性。综述了猪链球菌2型89K毒力岛的结构与进化过程, 以及国内外对毒力岛中二元信号转导系统、IV型分泌系统、ABC转运蛋白、毒素-抗毒素系统等重要基因的研究进展, 力图从基因水平为猪链球菌2型的致病机制寻找突破口。

Abstract:

The pathogenic mechanism of Streptococcus suis serotype 2 is still unsolved. Pathogenicity island not only gives pathogen special ability of pathogenic but also plays an important role in bacterial evolution process. Thorough analysis of the functional genes in 89K pathogenicity island contributes to a more comprehensive grasp of the characteristics of Streptococcus suis serotype 2. This paper summarized the structure and evolution process of 89K pathogenicity island and the research progress of domestic and foreign, including in two-component signal transduction system, type IV secretion system, ATP-binding cassette transporter protein, toxin-antitoxin system and other important genes, trying in gene level to find a breakthrough in pathogenesis of Streptococcus suis serotype 2.