多胺与细菌病原的致病性

The roles of polyamines on pathogenesis of bacterial pathogens

摘要:

多胺是一类具有两个以上氨基的脂肪族化合物, 它们在生物体内含量的动态平衡受合成、转运、降解及互换等过程的影响, 多胺及其合成和转运系统与病原菌的致病性相关。本文综述了多胺在细菌毒力因子的转录和翻译、细菌生物膜的合成、细菌对抗生素的抗性、细菌对抗宿主的酸性胁迫和氧化胁迫、细菌对抗宿主的先天免疫防御机制、细菌致病性生物分子的合成等方面的重要作用。

Abstract:

Polyamines are aliphatic compounds with two or more amino groups. The intracellular content of polyamines is regulated by the biosynthesis, transport, degradation and interconversion processes. The polyamines and their biosynthesis and transport mechanisms have important roles on the pathogenesis of bacterial pathogens. This review focuses on the roles of polyamines on the transcription and translation of virulence factors of bacteria, the formation of biofilm, the resistance to antibiotics, the resistance to the acid stress and oxidative stress in host, the biosynthesis of molecules involved in pathogenesis and the resistance to the host.