Abstract:The core curriculum reform of the bioengineering major has been investigated focusing on emphasizing the comprehensive qualities, enhancing the education of engineering ability and accomplishment, improving the knowledge structure. The engineering qualities contents were illuminated with the five kinds of capabilities and five kinds of awareness, which must be possessed by the bioengineer. The main core curriculum was determined for training the engineering qualities. Based on the cooperation of Industry-University-Research, the double qualified teachers’ were improved. Focusing on training the engineering ability, the characteristic course group was constructed by the main lines of bioengineering factory design and the technology improvement. The teaching methods of some core curriculum, for example, heuristic teaching, group discussion, comparison and summary method, etc. were put forward to increase the teaching efficiency and enhance the engineering qualities of the students.