葡萄球菌呼吸相关双组分系统SrrAB研究进展

Advances in two-component signal transduction system SrrAB of staphylococcus

摘要:

葡萄球菌呼吸相关双组分系统SrrAB能感应外界O2浓度, 并将信号传至胞内, 调控下游基因的转录, 以应对外界环境的变化。有研究表明, 金黄色葡萄球菌SrrAB在有氧条件下促进毒力因子的表达, 抑制生物膜的形成; 在厌氧条件下抑制毒力因子的表达, 促进生物膜的形成。另外, 在有氧及厌氧条件下, 金黄色葡萄球菌SrrAB调控生长代谢的途径也不一致。表皮葡萄球菌中也存在类似的双组分系统SrrAB, 且与金黄色葡萄球菌SrrAB具有较高同源性, 但目前尚不清楚两者在生长代谢及毒力调控方面的异同。结合课题组研究工作, 简要综述葡萄球菌SrrAB的调控机制, 着重比较其在有氧及厌氧条件下的调控差异, 这对临床诊治葡萄球菌引起的感染具有一定的借鉴意义。

Abstract:

Staphylococcus employs SrrAB, a two-component signal transduction system (TCSTS), to sense and respond to changes in oxygen tension by regulating transcriptions of downstream genes. It has been demonstrated that under aerobic condition SrrAB upregulates the expression of virulence factors and inhibits biofilm formation in S. aureus, however under anaerobic condition it downregulates the expression of virulence factors, and enhances biofilm formation. In addition, SrrAB plays different roles in growth and metabolism under aerobic and anaerobic conditions in S. aureus. Little is known about the function of SrrAB in S. epidermidis, which shares considerable homology with SrrAB of S. aureus. In combination with previous work of our laboratory, we review the advances of current research of staphylococcal SrrAB, with the comparison of SrrAB modulation mechanism under aerobic and anaerobic conditions highlighted.