The work-study combination personnel training mode has been approved in higher vocational education and teaching reform. At present, the key issue is how to implement the combination of production and learning and the cooperation between colleges and enterprises in the daily teaching. We propose the means of carrying out the work-study combination training mode in the teaching of biochemical technology based on our long-term teaching practice. We aim to explore a new path for the implement of the combination of production and learning by combining the teaching contents with the employment orientation, combining school classrooms with workshops, combining teachers in colleges with workers in enterprises, combining teaching process with production process and combining scientific research of colleges with factories.